Abstract: Aspirin is commonly prescribed as part of standard stroke recovery medication, but I know of no research done on the interaction of Aspirin with a ketogenic diet. In particular, salicylates are known to interfere with mitochondria, and in particular, lipolysis and beta-oxidation (the creation of ketones). Aspirin is known to up regulate and down regulate gene expression, often along with other substances. The purpose of this brief study is just to sound a warning to those already on a high plant food ketogenic diet.
A low carbohydrate diet, also high in vegetables, herbs and spices is potentially already blood thinning. In particular, these vegetables in our regular diet are high or very high in salicylates: green pepper, mushrooms, olives, tomato, broccoli, spinach and sweet potato. We also eat moderate amounts daily of these fruits very high in salicylates: apricots, blueberries, blackberries and raspberries. And then there are almonds and most of the spices I use in generous amounts! We would easily consume well over 50mg of salicylates every day.
While eating a high plant food diet is healthy, adding additional salicylate in the form of aspirin, may cause long-term toxic effects. Eating high salicylate foods which are rich in a whole variety of nutrients is quite different to consuming aspirin alone.
The Krebs cycle enzyme α-ketoglutarate dehydrogenase is inhibited by aspirin and salicylates, and worse, Alzheimer’s Disease (AD) appears to be associated with a decline in α-ketoglutarate dehydrogenase. There may be no causal link here, but if AD is a result of damaged mitochondria and oxidative stress, then taking aspirin long-term seems to be a very foolish thing.
(This page is incomplete and under development)!
What is Coming:
How Aspirin thins the blood.
What else does Aspirin (and/or salicylates) interfere with?
What research shows on preventing a second stroke – and comparison with Vitamin E.
(Just a lot of research to read & summarise)
Conclusion: I have no definitive answers on aspirin. It is potentially a powerful tool against an existing metastatic cancer. It is also possibly lifesaving in the short-term to people on a SAD diet. In the event of a stroke, an immediate dose of aspirin could be a life saver, and I would administer such a dose in this situation. For someone who is on a poor diet, in bad health, and refuses to consider a healthy life style, regular low dose aspirin may indeed reduce all cause mortality! They are already heading for an early death from cancer, heart disease, stroke or AD. Aspirin is unlikely to hasten their already expected early demise. However, for someone on a healthy, high plant food diet, rich in natural blood thinners, and salicylates, the regular use of aspirin may be ill-advised.